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Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research 

Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research
Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research

Jennifer C. Moore

, Michael Sheldon

, and Jay A. Tischfield

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date: 17 May 2022

The discovery that human primary cells such as nucleated blood cells or cultured skin fibroblasts can be reprogrammed into induced pluripotent stem cells (hiPSC) has ushered in a new era for research on the genetic etiology of neuropsychiatric disorders. Such hiPSC can be differentiated into several types of neurons, which may provide a primitive model for studying cellular variation in neuronal function due to underlying genetic variants causing the disorder. It is critical that source cells for possible reprogramming and their derived hiPSC be banked in an accredited facility capable of proper quality assurance that includes a genetic profile for future authentication of secondary biomaterials (e.g., differentiated cellular derivatives). Nucleated blood cells are more easily obtained compared to skin fibroblasts and can be cryopreserved for many years before they are reprogrammed to hiPSC. However, to enable all possible future uses of biosamples, some of which may not yet even be contemplated, researchers and biobanks must obtain clear informed consent from subjects for broad use of their biosamples in research.

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