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Animal Models 

Animal Models
Chapter:
Animal Models
Author(s):

Tadafumi Kato

DOI:
10.1093/med/9780190221973.003.0012
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date: 20 November 2019

Animal models of mental disorders are important for the development of new treatment and biomarkers. Animal models should satisfy three validity criteria. The choice of species used for animal models depends on the purposes of the study. There are several established models of chromosomal abnormalities for autism and schizophrenia. Stress-induced animal models of depression are controversial. There have been no established models for bipolar disorder, but the authors recently proposed a genetic animal model showing recurrent spontaneous depression-like episodes. Optogenetic manipulation of neural circuit is also used for modeling of mental disorders. Progress in psychiatric genetics will lead to the generation of valid animal models of psychiatric disorders.

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