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Decalcifying Agents 

Decalcifying Agents
Chapter:
Decalcifying Agents
Author(s):

M. A. Merchán

, J. DeFelipe

, and F. de Castro Soubriet

DOI:
10.1093/med/9780190221591.003.0003
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date: 23 September 2021

Decalcifying agents are acidic substances that combine with lime in bone salts, teeth, chitin, etc., forming water-soluble compounds that easily can be removed. Decalcificants are indispensable when serial sections are to be obtained from specimens like embryos, fetuses, or small animals, in which it is not possible to remove the bone protection of the neuraxis or of certain peripheral nerve endings (inner ear, teeth, etc.). A good example of the advantages of this treatment is the study of inner ear endings with neurofibrillary methods in newborn or young mice. Some of the available solutions are convenient for general purpose staining methods for the nervous system, whereas others are especially appropriate when silver impregnations are to be performed.

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