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Neuropathic Pain 

Neuropathic Pain
Neuropathic Pain

Ian M. Fowler

, Robert J. Hackworth

, and Erik P. Voogd

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date: 23 October 2019

Neuropathic pain encompasses a vast number of clinical conditions that share the common characteristic of pain resulting from nerve injury or damage. Upon injury, pathophysiologic changes in the peripheral nervous system occur, including hyperexcitability and the spontaneous generation of impulses (ectopia). As a result of these peripheral changes, alterations in signal processing and intrinsic changes within the central nervous system occur. All of these changes contribute to the generation of neuropathic pain. This chapter attempts to capture the essence of the objectives and goals set forth by the International Association for the Study of Pain’s Core Curriculum for Professional Education in Pain for the topic of neuropathic pain. The questions cover topics including definitions, common clinical conditions, uncommon clinical conditions, therapeutic interventions, pathophysiological mechanisms, and current investigations.

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