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Polytherapy With Antiepileptic Drugs 

Polytherapy With Antiepileptic Drugs
Polytherapy With Antiepileptic Drugs

Ali A. Asadi-Pooya

and Michael R. Sperling

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date: 11 August 2020

About 40% of patients with epilepsy will have “difficult-to-control” seizures. If seizure control is greatly improved but seizure freedom is not achieved by a single antiepileptic drug (AED), another AED may be added to the first agent (i.e., polytherapy). Many physicians advocate combination therapy once two have failed in monotherapy.

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