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Antiepileptic Drugs and Metabolic Disorders 

Antiepileptic Drugs and Metabolic Disorders
Antiepileptic Drugs and Metabolic Disorders

Ali A. Asadi-Pooya

and Michael R. Sperling

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date: 04 August 2020

Three antiepileptic drugs—acetazolamide, topiramate, and zonisamide—are typically associated with metabolic acidosis due to their property of inhibiting the enzyme carbonic anhydrase. Hyponatremia occurs in patients treated with carbamazepine, oxcarbazepine, or eslicarbazepine acetate. Hyperammonemia can occur in as many as half of patients receiving valproic acid.

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