Figure 4.1 The statistical power for reaching genome-wide significance (p = 5 × 10-8) in an association test increases with sample size, the estimated odds ratio of the association, and with the minor allele frequency (MAF) of the variant. The figure visualizes this relationship for a MAF of 10% and three selected odds ratios. The plot has been generated using the function power.prop.test() of the R package pwr.