Treatment of Neurodevelopmental DisordersTargeting Neurobiological Mechanisms

Treatment of Neurodevelopmental DisordersTargeting Neurobiological Mechanisms

Randi J. Hagerman and Robert L. Hendren

Print publication date: Jul 2014

ISBN: 9780199937806

Publisher: Oxford University Press

Abstract

Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. This online resource summarizes for the practicing clinician the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail, including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology, and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. It also highlights the commonalities across disorders and new genetic and molecular concepts.