Huntington's Disease

Huntington's Disease

Gillian Bates, Sarah Tabrizi, and Lesley Jones

Print publication date: Mar 2014

ISBN: 9780199929146

Publisher: Oxford University Press

Abstract

This fourth edition of Huntington's disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections, which include clinical aspects of Huntington's disease (historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and juvenile Huntington's), the genetics of Huntington's disease (epidemiology discussions of new testing guidelines), neurobiology (correlations between pathology and symptoms and neuronal circuitry), the molecular biology of Huntington's disease (the normal function of huntingtin, molecular pathogenesis, the peripheral pathology of the disorder, and structural biology), and an updated description of the comprehensive care for Huntington's disease (preclinical therapeutics and the state of the art of experimental therapeutics and clinical trials).