
Neuroglia
Helmut Kettenmann and Bruce R. Ransom
Print publication date: Dec 2012
ISBN: 9780199794591
Publisher: Oxford University Press
Abstract
This resource is the long-awaited new revision of the most highly regarded reference volume on glial cells, and has been completely revised, greatly enlarged, and enhanced with full color figures throughout. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. With more than 20 new chapters it addresses the massive growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function.
Table of Contents
- Front Matter
- Section 1 Properties of Neuroglial
Cells
- Evolution of Glial Cells: Insights from Non-Mammalian Glia
- Morphology, Ultrastructure, and Identification
- Lineage and Development
- Physiological Properties
- 16. Physiology of Astrocytes: Ion Channels and Ion Transporters
- 17. Release of Gliotransmitters and Transmitter Receptors in Astrocytes
- 18. Storage and Release of Nontransmitter Signaling Molecules from Macroglia
- 19. Physiology of Microglia
- 20. Physiology of Oligodendrocytes
- 21. Physiological Properties of NG2+ Glial Cells
- 22. Cytokine, Chemokine, and Growth Factor Receptors and Signaling
- 23. Lipids, Lipid Mediators, and Other Signaling Molecules
- 24. Gap Junctions and Hemichannels
- 25. Purinergic Mechanisms in Glial Cells
- 26. Calcium Signaling in Neuroglia
- 27. The Central Role of Astrocytes in Neuroenergetics
- Genomic Profiles
- Section 2 Functions of Neuroglial
Cells
- Astrocytes
- 30. Neurogenesis and Outer Subventricular Zone Radial Glial Cells
- 31. Glial Control of Synaptogenesis
- 32. Neuron Migration and Axon Guidance
- 33. The Role of Glia in the Formation and Function of the Blood-Brain Barrier
- 34. Control of the Extracellular Ionic Environment and Volume
- 35. Amino Acid Neurotransmitter Synthesis and Removal
- 36. Glycogen and Energy Metabolism
- 37. Astrocyte Regulation of Neurovascular Control
- 38. Astrocytes: Modulation of Synaptic Function and Network Activity
- 39. Astrocytic Modulation of Mammalian Synapses: Circuits and Behaviors
- 40. Adult Neurogenesis
- 41. Modulation of Neuroendocrine Systems
- Oligodendrocytes/Schwann Cells
- Microglia
- Astrocytes
- Section 3 Role of Glial Cells in Disease
- End Matter