The AutismsMolecules to Model Systems

The AutismsMolecules to Model Systems

Craig M. Powell and Lisa M. Monteggia

Print publication date: Dec 2012

ISBN: 9780199744312

Publisher: Oxford University Press

Abstract

This resource discusses the identification of potential therapeutic targets for autism that can be tested in genetic models and hopefully translated into novel, rational therapies. It provides a roadmap to multitude of relatively rare mutations that have been identified as causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, this resource aids the understanding of the pathophysiology of autism and ultimately to identifying novel treatments.