Page of

Advanced pancreatic cancer: Advanced pancreatic cancer Expert commentary Pippa Corrie Expert commentary Pippa Corrie 

Advanced pancreatic cancer: Advanced pancreatic cancer Expert commentary Pippa Corrie Expert commentary Pippa Corrie
Chapter:
Advanced pancreatic cancer: Expert commentary Pippa Corrie
Source:
Challenging Concepts in Oncology
Author(s):

Bristi Basu

, and Gary Doherty

DOI:
10.1093/med/9780199688883.003.0009

Improving outcomes in pancreatic adenocarcinoma remains a key challenge, and few advances have yet impacted significantly on life expectancy; the overall 5-year survival rate remains less than 5%, even including patients undergoing surgical resection. This case history illustrates the difficulties in diagnosis and the complexity of this disease. Most patients present too late for curative surgery, and symptom palliation involves multidisciplinary approaches to relieve common problems associated with obstructive jaundice, pain, cachexia, and ascites. Venous thromboembolism is also common, and its management discussed here. Although responses to chemotherapy and radiotherapy are poor, systemic therapy has been established as an effective adjuvant for those patients identified early enough to undergo surgery, whilst, in advanced disease, recent approaches to combination chemotherapy may offer modest improvements in life expectancy. However, drug-induced toxicity limits patients <tolerance of treatment. Considerable hope lies in a better understanding of the molecular characteristics of this disease, which may yield novel targets for therapeutic intervention.

Sign In

Copyright © 2020. All rights reserved.