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HIV-associated malignancies: HIV-associated malignancies Expert commentary Mark Bower Expert commentary Mark Bower 

HIV-associated malignancies: HIV-associated malignancies Expert commentary Mark Bower Expert commentary Mark Bower
Chapter:
HIV-associated malignancies: Expert commentary Mark Bower
Source:
Challenging Concepts in Oncology
Author(s):

Kate Smith

DOI:
10.1093/med/9780199688883.003.0023

The case history outlines the diagnostic and management challenges of treating immunosuppression-associated malignancies, using, as example, a patient newly diagnosed with HIV and human herpes virus-8 (HHV-8)-driven multicentric Castleman disease (MCD) who subsequently develops plasmablastic lymphoma, a second HHV-8-associated malignancy. The aetiology, diagnosis, and management of common HIV-associated malignancies are outlined. Management of this patient group is often challenging. Specific considerations, such as treatment-associated toxicity, the risk of opportunistic infections, drug interactions, and the increased risk of relapse and second malignancy, are discussed. Strategies to prevent HIV-associated malignancies are also outlined.

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