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Neuroendocrine tumours and treatment complications: Neuroendocrine tumours and treatment complications Expert commentary Juan W Valle Expert commentary Juan W Valle 

Neuroendocrine tumours and treatment complications: Neuroendocrine tumours and treatment complications Expert commentary Juan W Valle Expert commentary Juan W Valle
Chapter:
Neuroendocrine tumours and treatment complications: Expert commentary Juan W Valle
Source:
Challenging Concepts in Oncology
Author(s):

Angela Lamarca

DOI:
10.1093/med/9780199688883.003.0022

Neuroendocrine tumours (NETs) are epithelial neoplasms with predominant neuroendocrine differentiation which can arise in most organs of the body; gastroenteropancreatic (GEP)-NETs are those arising from the digestive tract. NETs vary considerably with respect to the functionality (evidenced by excessive hormone secretion) and the clinical and biological behaviour. Updates in the terminology, classification, and advances in therapy options for these tumours have changed their management. The important aspects of diagnosis, clinical presentation, and treatment options are reviewed in this case, with a special focus on available therapies for metastatic GEP-NETs, including somatostatin analogues, radionuclide therapies, interferon (IFN), and chemotherapy, as well as novel targeted therapies, namely everolimus and sunitinib, reviewing the most relevant data.

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