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Glioblastoma multiforme (GBM): Glioblastoma multiforme (GBM) Expert commentary Eliot Sims Expert commentary Eliot Sims 

Glioblastoma multiforme (GBM): Glioblastoma multiforme (GBM) Expert commentary Eliot Sims Expert commentary Eliot Sims
Chapter:
Glioblastoma multiforme (GBM): Expert commentary Eliot Sims
Source:
Challenging Concepts in Oncology
Author(s):

Kathryn Tarver

DOI:
10.1093/med/9780199688883.003.0020

Central nervous system (CNS) malignancies vary widely in their morphological and clinical characteristics, the varying patient groups affected, as well as in terms of outcome. Of all the CNS malignancies, glioblastoma multiforme (GBM) is arguably the most devastating. In spite of practice-changing studies in recent years that have impacted favourably on the outcome in GBM, the prognosis remains limited. This chapter focusses on a typical case of a previously fit and well middle-aged patient presenting with symptoms of raised intracranial pressure (ICP) who is found to have GBM. Building on the case and management of this patient, it details standard first-line management of the condition with surgery, chemoradiation, and chemotherapy, exploring the evidence behind current clinical practice. Additional information is given on subtopics such as the management of seizures and raised ICP, the clinical and radiological phenomenon of pseudoprogression, as well as MGMT promoter methylation and its significance in the management of patients with GBM.

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