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Metastatic prostate cancer and spinal cord compression: Metastatic prostate cancer and spinal cord compression Expert commentary Helen O’Donnell Expert commentary Helen O’Donnell 

Metastatic prostate cancer and spinal cord compression: Metastatic prostate cancer and spinal cord compression Expert commentary Helen O’Donnell Expert commentary Helen O’Donnell
Chapter:
Metastatic prostate cancer and spinal cord compression: Expert commentary Helen O’Donnell
Source:
Challenging Concepts in Oncology
Author(s):

Indrani Bhattacharya

DOI:
10.1093/med/9780199688883.003.0014

The managements of localized and metastatic prostate cancer are distinct. Prostate cancer management has undergone many changes, due to developments in our understanding of the natural history of prostate cancer and its response to treatment, and the introduction of functional imaging and technological advances in both radiotherapy and surgery. This case demonstrates the issues surrounding diagnosis and risk stratification of prostate cancer, such that treatment options can be presented and an informed decision made. The issue of prostate-specific antigen recurrence, subsequent metastatic disease, and its sequelae are discussed. There have been significant advances in drug development in metastatic prostate cancer, which have been discussed, as well as the diagnosis and management of spinal cord compression. The limitations of success from radical local treatment relate either to resistant disease locally or the presence of early micrometastatic disease at diagnosis, which is not treated with local therapy.

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