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Colorectal liver metastases: Colorectal liver metastases Expert commentary Nick Maisey Expert commentary Nick Maisey 

Colorectal liver metastases: Colorectal liver metastases Expert commentary Nick Maisey Expert commentary Nick Maisey
Chapter:
Colorectal liver metastases: Expert commentary Nick Maisey
Source:
Challenging Concepts in Oncology
Author(s):

Khurum Khan

DOI:
10.1093/med/9780199688883.003.0011

Colorectal cancer (CRC) remains the second commonest cause of cancer-related mortality in the world. There have been significant advances in the treatment of metastatic CRC, particularly in the management of CRC with liver metastases. These advances are primarily driven by the development of active targeted agents for use in both the neoadjuvant and metastatic setting; however, these drugs work best when combined with conventional chemotherapy agents. Despite these advances, there remains a paucity of predictive biomarkers to inform us about the most effective management of these patients. It is therefore imperative to select carefully the patients, with comprehensive multidisciplinary team (MDT) input, in order to optimize the management of these patients. This chapter describes a case of colorectal liver metastases and its management within the MDT and the toxicities associated with systemic therapy. Specifically discussed are the management of capecitabine-induced diarrhoea, cetuximab-associated rash, and neuropathy with oxaliplatin.

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