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Imaging non-motor aspects of Parkinson’s disease 

Imaging non-motor aspects of Parkinson’s disease
Chapter:
Imaging non-motor aspects of Parkinson’s disease
Source:
Non-motor Symptoms of Parkinson's Disease (2 ed.)
Author(s):

David J. Brooks

and Nicola Pavese

DOI:
10.1093/med/9780199684243.003.0006

Positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) have made an enormous contribution to the understanding of the pathophysiological and pharmacological mechanisms underlying the motor complications of Parkinson’s disease (PD) and other movement disorders. These neuroimaging techniques enable one to investigate in vivo the function of the basal ganglia, their cortical projection areas and other brainstem nuclei in both healthy subjects and patients. In PD, PET and SPECT have been employed to evaluate the following: patterns of change in cerebral metabolism related to the disease and dysfunction of pre-synaptic dopaminergic terminals; the availability of post-synaptic dopaminergic receptors and changes in brain dopamine levels during akinesia and dyskinesia; and the contribution of non-dopaminergic neurotransmitters to motor and non-motor complications of PD.

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