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Thermoregulatory dysfunction in Parkinson’s disease 

Thermoregulatory dysfunction in Parkinson’s disease
Thermoregulatory dysfunction in Parkinson’s disease
Non-motor Symptoms of Parkinson's Disease (2 ed.)

Giovanni Mostile

and Joseph Jankovic


In humans, as in all mammals, the core body temperature is maintained within a narrow range by physiological homeostatic feedback mechanisms that are driven by the autonomic and endocrine systems. After the initial vasomotor tone adjustment, sweating and shivering responses are activated at different thresholds for the determination of heat loss (HL) and heat production (HP) in response to ambient temperature variations. Patients with Parkinson#amp;#x2019;s disease (PD) can be affected by dysregulation of body temperature, dysthermesthesia and dyshidrosis depending on differential involvement of the mechanisms regulating core temperature. Thermoregulatory dysfunction in PD gradually worsen with time as the disease progresses. Co-morbidities, such as dehydration with hypovolaemia and infection, should be screened in patients with PD to correctly identify and treat possible secondary causes.

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