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Treatment-related non-motor symptoms in Parkinson’s disease 

Treatment-related non-motor symptoms in Parkinson’s disease
Treatment-related non-motor symptoms in Parkinson’s disease
Non-motor Symptoms of Parkinson's Disease (2 ed.)

Vincent Ries

, J. Carsten Möller

, Marcus M. Unger

, and Wolfgang H. Oertel


Pharmacotherapy is the basis of treatment of Parkinson’s disease and there are effective medications, especially in the early stages. However, a number of possible side effects related to antiparkinsonian therapy need to be considered. This chapter describes non-motor symptoms attributable to antiparkinsonian medication. These include rare but serious side effects such as serotonin syndrome and malignant neuroleptic syndrome. Data on chronic side effects such as ergot-related fibrosis and cardiac valvulopathy are also reviewed in detail. Furthermore, medication-induced fluctuation of mood, cognition and perception is exemplified. Lastly, the chapter describes how the disease process and dopamimetic medication contribute to excessive daytime sleepiness and notes advice for patients affected by this condition. A number of tables are included detailing the pharmacological properties and effects of selected dopamimetic drugs.

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