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Impulse dyscontrol and dopamine dysregulation syndrome 

Impulse dyscontrol and dopamine dysregulation syndrome
Chapter:
Impulse dyscontrol and dopamine dysregulation syndrome
Source:
Non-motor Symptoms of Parkinson's Disease (2 ed.)
Author(s):

Regina Katzenschlager

and Andrew Evans

DOI:
10.1093/med/9780199684243.003.0028

Dopaminergic medications used to treat Parkinson’s disease (PD) improve symptoms, reduce motor handicap and may prolong survival. However, in some individuals they may induce a range of disabling symptoms beyond those attributable to the disease process. These include a variety of compulsive and addictive behaviours. The term ‘dopamine dysregulation syndrome’ (DDS) refers to the compulsive use of dopaminergic medications well beyond the dose needed to optimally control motor disability and in the face of a mounting number of harmful physical, psychiatric and social sequelae. Impulse control disorders (ICDs), defined as the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the person or to others, may be induced by dopaminergic therapy, particularly dopamine agonists. Moreover, ICDs are seen frequently in patients with DDS, indicating a global sensitizing effect of dopaminergic drugs on motivational systems.

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