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Excessive daytime sleepiness in Parkinson’s disease 

Excessive daytime sleepiness in Parkinson’s disease
Chapter:
Excessive daytime sleepiness in Parkinson’s disease
Source:
Non-motor Symptoms of Parkinson's Disease (2 ed.)
Author(s):

Birgit Frauscher

and Werner Poewe

DOI:
10.1093/med/9780199684243.003.0016

While in his ‘Essay on the shaking palsy’, James Parkinson referred to excessive sleepiness as an end-stage feature of the disease now bearing his name, different manifestations of dysregulation of the sleep–wake cycle have meanwhilebecome recognised as common non-motor problems across all stages of Parkinson’s disease (PD) and rapid eye movement sleep behaviour disorder may even occur as a ‘pre-clinical’ sign prior to the development of the cardinal motor symptoms. Depending on the definition and type of assessment, excessive daytime sleepiness has been found in up to 50% of patients and episodes of sudden-onset sleep have now been identified as an important adverse reaction to dopaminergic therapy—in particular with dopamine agonists. This chapter will review current definitions, prevalence, underlying mechanisms as well as treatment of excessive daytime sleepiness in PD.

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