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Dementia in Parkinson’s disease 

Dementia in Parkinson’s disease
Chapter:
Dementia in Parkinson’s disease
Source:
Non-motor Symptoms of Parkinson's Disease (2 ed.)
Author(s):

David J. Burn

and Alison J. Yarnall

DOI:
10.1093/med/9780199684243.003.0010

As this chapter reveals, dementia is a common complication of Parkinson’s disease, occurring in up to 80% of people with the disease. Dementia associated with Parkinson’s disease (PDD) and dementia with Lewy bodies are part of a Lewy body disease spectrum, underpinned by abnormalities of α‎-synuclein metabolism. The clinical profile of PDD is classically a dysexecutive-visuoperceptual dementia, almost invariably accompanied by significant neuropsychiatric features, notably psychotic manifestations. Biological candidates to account for the clinical expression of PDD include Lewy bodies and synuclein pathology, Alzheimer-type pathology, vascular changes, neuronal loss and neurochemical deficits. The management of PDD is complex and difficult, and often requires compromise. Antipsychotic agents are of limited benefit, and cholinesterase inhibitors are currently the mainstay of drug treatment.

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