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Electrophysiology 

Electrophysiology
Chapter:
Electrophysiology
Source:
Oxford Textbook of Rheumatology (4 ed.)
Author(s):

Julian Blake

DOI:
10.1093/med/9780199642489.003.0074

Clinical neurophysiology is a diagnostic discipline used in the assessment of peripheral and central neurological disease. Sensory action potential and compound muscle action potential measurement in peripheral neurological disorders is outlined in this chapter. Amplitude of action potentials gives information about axon integrity, whereas conduction velocity is related to the state of myelin. These parameters are used to identify and localize entrapment neuropathies and provide useful management and prognostic information. They are essential in the diagnosis of axonal and demyelinating peripheral neuropathies. Needle electromyography is used to characterize the cause of weakness, distinguishing denervation from myopathies. Simple neurophysiological methods are also applicable to the diagnosis of neuromuscular junction disorders.

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