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Complement 

Complement
Chapter:
Complement
Source:
Oxford Textbook of Rheumatology (4 ed.)
Author(s):

Matthew C. Pickering

and Jyoti Bakshi

DOI:
10.1093/med/9780199642489.003.0064_update_001
Previous versions of this chapter are available. To view earlier versions of this chapter view the full site here.

In this chapter we summarize clinically important aspects of complement biology. This information is used to present a comprehensive overview of complement deficiency states and provide a logical basis for understanding complement assays in clinical practice. Hypocomplementaemic urticarial vasculitis syndrome, a condition associated with anti-C1q antibodies and complement consumption, is discussed. We summarize the use of eculizumab, a monoclonal antibody that targets and inhibits complement C5, in the treatment of haemolysis in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome.

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