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Skeletal muscle physiology and damage 

Skeletal muscle physiology and damage
Chapter:
Skeletal muscle physiology and damage
Source:
Oxford Textbook of Rheumatology (4 ed.)
Author(s):

Robert Dinser

and Ulf Müller-Ladner

DOI:
10.1093/med/9780199642489.003.0055_update_001
Previous versions of this chapter are available. To view earlier versions of this chapter view the full site here.

This chapter summarizes muscle structure and physiology, the genesis and adaptions of muscle throughout life, and clinical assessment of muscle disease. The anatomical and molecular structure of muscle tissue is described, as well as the basic function of the neuromuscular junction, the energy metabolism of muscle tissue, and the mechanisms of fatigue. Key elements of embryological myogenesis, the adaptions of muscle to exercise and damage, and physiological ageing are depicted. A summary of the clinical analysis of muscle function including laboratory, electrophysiological, and imaging testing is provided.

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