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Genetics of spondyloarthropathies 

Genetics of spondyloarthropathies
Chapter:
Genetics of spondyloarthropathies
Source:
Oxford Textbook of Rheumatology (4 ed.)
Author(s):

Matthew Brown

DOI:
10.1093/med/9780199642489.003.0041_update_004
Previous versions of this chapter are available. To view earlier versions of this chapter view the full site here.

Spondyloarthropathies are a diverse group of conditions, of which ankylosing spondylitis is the prototypic disease, with shared clinical features, genetic risk factors, and histopathological characteristics. These conditions are highly familial and heritable. Several genes have been associated with spondyloarthropathies, with genes in the IL-23 signalling pathway being shared by the major types of spondyloarthritis. These discoveries have already led to the development and successful clinical introduction of novel treatments for psoriasis and psoriatic arthritis, and major advances in our understanding of the pathogenesis of the conditions. Many more genes remain to be identified which are involved in these common conditions; identifying these genes is likely to be highly informative as to their causes.

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