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Lyme borreliosis 

Lyme borreliosis
Chapter:
Lyme borreliosis
Source:
Oxford Textbook of Rheumatology (4 ed.)
Author(s):

Andreas Krause

and Volker Fingerle

DOI:
10.1093/med/9780199642489.003.0101_update_002
Previous versions of this chapter are available. To view earlier versions of this chapter view the full site here.

Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that may cause acrodermatitis chronica atrophicans, chronic neuroborreliosis of the central nervous system, or antibiotic resistant Lyme arthritis. However, even these chronic manifestations usually slowly regress after thorough antibiotic and symptomatic therapy, although in part with irreversible organ defects.

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