
Oxford Textbook of Clinical NephrologyThree-Volume Pack
Neil N. Turner, Neil N. Turner, Norbert Lameire, David J. Goldsmith, Christopher G. Winearls, Jonathan Himmelfarb, and Giuseppe Remuzzi
Print publication date: Oct 2015
ISBN: 9780199592548
Publisher: Oxford University Press
Abstract
With expert input from additional section editors William G. Bennett, Jeremy R. Chapman, Adrian Covic, Marc E. De Broe, Vivekanand Jha, Neil Sheerin, Robert Unwin, and Adrian Woolf, the Oxford Textbook of Clinical Nephrology is a three-volume international textbook of nephrology with an unrivalled clinical approach backed up by science. It has been completely rewritten in 365 chapters for its fourth edition to bring it right up to date, make it easier to obtain rapid answers to questions, and to suit delivery in electronic formats as well as in print. This edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. The target audience is primarily the nephrologist in clinical practice and training as well as other healthcare professionals with an interest in renal disease.
Table of Contents
- Front Matter
- Section 1 Assessment of the patient with renal disease
- Chapter 1 Epidemiology of kidney disease
- Chapter 2 Clinical assessment of the patient with renal disease: overview
- Chapter 3 Presentations of renal disease
- Chapter 4 Kidney disease-focused history taking
- Chapter 5 Kidney disease-focused features on examination
- Chapter 6 Urinalysis
- Chapter 7 Assessment of renal function
- Chapter 8 Tubular function
- Chapter 9 Renal radiology: overview
- Chapter 10 Ionizing radiation and radiation protection
- Chapter 11 Plain radiography, excretion radiography, and contrast radiography
- Chapter 12 Intervention
- Chapter 13 Ultrasound
- Chapter 14 Computed tomography
- Chapter 15 Magnetic resonance imaging
- Chapter 16 Radioisotopes in diagnostic imaging in nephrology
- Chapter 17 Immunological investigation of the patient with renal disease
- Chapter 18 The renal biopsy
- Chapter 19 Clinical trials: why and how in nephrology
- Section 2 The Patient with fluid, electrolyte, and renal tubular disorders
- Chapter 20 An overview of tubular function
- Chapter 21 Sodium transport and balance: a key role for the distal nephron
- Chapter 22 Water homeostasis
- Chapter 23 Potassium homeostasis
- Chapter 24 Renal acid–base homeostasis
- Chapter 25 Phosphate homeostasis
- Chapter 26 Calcium homeostasis
- Chapter 27 Magnesium homeostasis
- Chapter 28 Approach to the patient with hyponatraemia
- Chapter 29 Approach to the patient with hypernatraemia
- Chapter 30 Approach to the patient with oedema
- Chapter 31 Approach to the patient with salt-wasting tubulopathies
- Chapter 32 Approach to the patient with polyuria
- Chapter 33 Clinical use of diuretics
- Chapter 34 Approach to the patient with hypo-/hyperkalaemia
- Chapter 35 Approach to the patient with metabolic acidosis or alkalosis
- Chapter 36 Approach to the patient with renal tubular acidosis
- Chapter 37 Approach to the patient with hypercalcaemia
- Chapter 38 Approach to the patient with hypocalcaemia
- Chapter 39 Approach to the patient with hypo-/hyperphosphataemia
- Chapter 40 Approach to the patient with hypomagnesaemia
- Chapter 41 Approach to the patient with renal Fanconi syndrome, glycosuria, or aminoaciduria
- Section 3 The patient with glomerular disease
- Chapter 42 The glomerulus and the concept of glomerulonephritis
- Chapter 43 The renal glomerulus: the structural basis of ultrafiltration
- Chapter 44 Function of the normal glomerulus
- Chapter 45 Mechanisms of glomerular injury: overview
- Chapter 46 The patient with haematuria
- Chapter 47 Loin pain haematuria syndrome
- Chapter 48 Nutcracker syndrome and phenomenon
- Chapter 49 Exercise-related pseudonephritis
- Chapter 50 Proteinuria
- Chapter 51 Postural proteinuria (benign orthostatic proteinuria)
- Chapter 52 Nephrotic syndrome
- Chapter 53 Pathophysiology of oedema in nephrotic syndrome
- Chapter 54 Idiopathic nephrotic syndrome: overview
- Chapter 55 Minimal change disease: clinical features and diagnosis
- Chapter 56 Minimal change disease: treatment and outcome
- Chapter 57 Primary focal segmental glomerulosclerosis: clinical features and diagnosis
- Chapter 58 Primary focal segmental glomerulosclerosis: treatment and outcome
- Chapter 59 Pathogenesis of proteinuria in minimal change disease and focal segmental glomerulosclerosis
- Chapter 60 Membranous glomerulonephritis: overview
- Chapter 61 Membranous glomerulonephritis: clinical features and diagnosis
- Chapter 62 Membranous glomerulonephritis: treatment and outcome
- Chapter 63 Secondary membranous glomerulonephritis
- Chapter 64 Membranous glomerulonephritis: pathogenesis
- Chapter 65 Immunoglobulin A nephropathy: overview
- Chapter 66 Immunoglobulin A nephropathy: clinical features
- Chapter 67 Immunoglobulin A nephropathy diagnosis
- Chapter 68 Immunoglobulin A nephropathy: treatment and outcome
- Chapter 69 Immunoglobulin A nephropathy: pathogenesis
- Chapter 70 Crescentic (rapidly progressive) glomerulonephritis
- Chapter 71 Antiglomerular basement membrane disease: overview
- Chapter 72 Antiglomerular basement membrane disease: clinical features and diagnosis
- Chapter 73 Antiglomerular basement membrane disease: treatment and outcome
- Chapter 74 Antiglomerular basement membrane disease: pathogenesis
- Chapter 75 Alport post-transplant antiglomerular basement membrane disease
- Chapter 76 Post-infectious glomerulonephritis: overview
- Chapter 77 Post-streptococcal glomerulonephritis
- Chapter 78 Immunoglobulin A-dominant post-infectious glomerulonephritis
- Chapter 79 Glomerulonephritis associated with endocarditis, deep-seated infections, and shunt nephritis
- Chapter 80 Membranoproliferative glomerulonephritis and C3 glomerulopathy
- Chapter 81 Fibrillary and immunotactoid glomerulopathy
- Chapter 82 Drug-induced and toxic glomerulopathies
- Section 4 The patient with interstitial disease
- Chapter 83 Acute tubulointerstitial nephritis: overview
- Chapter 84 Drug-induced acute tubulointerstitial nephritis
- Chapter 85 Other toxic acute tubulointerstitial nephritis
- Chapter 86 Chronic tubulointerstitial nephritis: overview
- Chapter 87 Drug-induced chronic tubulointerstitial nephritis
- Chapter 88 Heavy metal-induced tubulointerstitial nephritis
- Chapter 89 Aristolochic acid nephropathy caused by ingestion of herbal medicinal products
- Chapter 90 Balkan endemic nephropathy
- Chapter 91 Radiation nephropathy
- Chapter 92 Urate nephropathy
- Chapter 93 Immune-mediated tubulointerstitial nephritis
- Section 5 The patient with reduced renal function
- Chapter 94 Chronic kidney disease: definition, classification, and approach to management
- Chapter 95 Chronic kidney disease in the developed world
- Chapter 96 Chronic kidney disease in developing countries
- Chapter 97 Chronic kidney disease long-term outcomes: progression, death, cardiovascular disease, infections, and hospitalizations
- Chapter 98 Cardiovascular disease and chronic kidney disease: overview
- Chapter 99 Recommendations for management of high renal risk chronic kidney disease
- Chapter 100 Hypertension as a cause of chronic kidney disease: what is the evidence?
- Chapter 101 Diet and the progression of chronic kidney disease
- Chapter 102 Lipid disorders of patients with chronic kidney disease
- Chapter 103 Smoking in chronic kidney disease
- Chapter 104 Analytical aspects of measurements and laboratory values in kidney disease
- Chapter 105 Effect of lifestyle modifications on patients with chronic kidney disease
- Chapter 106 Malnutrition, obesity, and undernutrition in chronic kidney disease
- Chapter 107 Left ventricular hypertrophy in chronic kidney disease
- Chapter 108 Sudden cardiac death in chronic kidney disease
- Chapter 109 Epidemiology of calcium, phosphate, and parathyroid hormone disturbances in chronic kidney disease
- Chapter 110 The role of inflammation in chronic kidney disease
- Chapter 111 Vascular stiffness in chronic kidney disease: pathophysiology and implications
- Chapter 112 Oxidative stress and its implications in chronic kidney disease
- Chapter 113 Abnormal endothelial vasomotor and secretory function
- Chapter 114 Endothelins and their antagonists in chronic kidney disease
- Chapter 115 Chronic kidney disease-mineral and bone disorder: overview
- Chapter 116 Imaging for detection of vascular disease in chronic kidney disease patients
- Chapter 117 Pathophysiology of chronic kidney disease-mineral and bone disorder
- Chapter 118 Management of chronic kidney disease-mineral and bone disorder
- Chapter 119 Fibroblast growth factor 23, Klotho, and phosphorus metabolism in chronic kidney disease
- Chapter 120 Vascular calcification
- Chapter 121 Fractures in patients with chronic kidney disease
- Chapter 122 Spectrum of bone pathologies in chronic kidney disease
- Chapter 123 Clinical aspects and overview of renal anaemia
- Chapter 124 Erythropoiesis-stimulating agents in chronic kidney disease
- Chapter 125 Iron metabolism in chronic kidney disease
- Chapter 126 Iron management in renal anaemia
- Chapter 127 Pleiotropic effects of vitamin D
- Chapter 128 Immunity
- Chapter 130 Gastroenterology and renal medicine
- Chapter 131 Cutaneous manifestations of end-stage renal disease
- Chapter 132 The patient with reduced renal function: endocrinology
- Chapter 133 Sexual dysfunction
- Chapter 134 Health-related quality of life and the patient with chronic kidney disease
- Chapter 135 Coagulopathies in chronic kidney disease
- Chapter 136 Mechanisms of progression of chronic kidney disease: overview
- Chapter 137 Proteinuria as a direct cause of progression
- Chapter 138 Nephron numbers and hyperfiltration as drivers of progression
- Chapter 139 Podocyte loss as a common pathway to chronic kidney disease
- Chapter 140 Disordered scarring and failure of repair
- Chapter 141 Modality selection for renal replacement therapy
- Chapter 142 Patient education and involvement in pre-dialysis management
- Chapter 143 Preparation for renal replacement therapy
- Chapter 144 Choices and considerations for in-centre versus home-based renal replacement therapy
- Chapter 145 Conservative care in advanced chronic kidney disease
- Chapter 146 Palliative care in end-stage renal disease
- Chapter 147 Patient selection when resources are limited
- Chapter 148 Acidosis in chronic kidney disease
- Section 6 The patient with another primary diagnosis
- Chapter 149 The patient with diabetes mellitus
- Chapter 150 Kidney involvement in plasma cell dyscrasias
- Chapter 151 The patient with cryoglobulinaemia
- Chapter 152 The patient with amyloidosis
- Chapter 153 The patient with myeloma
- Chapter 154 Light-chain deposition disease
- Chapter 155 Other consequences from monoclonal immunoglobulins/fragments: Membranoproliferative glomerulonephritis and acquired Fanconi syndrome
- Chapter 156 The patient with sarcoidosis
- Chapter 157 The patient with vasculitis: overview
- Chapter 158 The patient with vasculitis: pathogenesis
- Chapter 159 The patient with vasculitis: clinical aspects
- Chapter 160 The patient with vasculitis: treatment and outcome
- Chapter 161 The patient with systemic lupus erythematosus: overview and pathogenesis
- Chapter 162 The patient with systemic lupus erythematosus: clinical features, investigations, and diagnosis
- Chapter 163 The patient with systemic lupus erythematosus: treatment and outcome
- Chapter 164 The patient with antiphospholipid syndrome with or without lupus
- Chapter 165 The patient with scleroderma: systemic sclerosis
- Chapter 166 The patient with rheumatoid arthritis, mixed connective tissue disease, Sjögren syndrome, or polymyositis
- Chapter 167 The patient with sickle cell anaemia
- Chapter 168 The obese patient (metabolic syndrome)
- Chapter 169 The patient with hepatorenal syndrome
- Chapter 170 Kidney/ear syndromes
- Chapter 171 Kidney/eye syndromes
- Chapter 172 The patient with renal cell cancer
- Chapter 173 The patient with Wilms tumour
- Chapter 174 The patient with haemolytic uraemic syndrome/thrombotic thrombocytopenic purpura
- Section 7 The patient with urinary tract infection
- Chapter 175 Urinary tract infection in the adult: overview
- Chapter 176 Infection of the lower urinary tract
- Chapter 177 Upper urinary tract infection
- Chapter 178 Complicated urinary tract infection
- Chapter 179 Urinary tract infection in a patient with a kidney transplant
- Chapter 180 Urinary tract infection in infancy and childhood
- Chapter 181 Schistosomiasis: the parasite and the host
- Chapter 182 Schistosomiasis: clinical impact
- Section 8 The patient with infections causing renal disease
- Chapter 183 Malaria
- Chapter 184 Leishmaniasis and trypanosomiasis
- Chapter 185 Hepatitis B
- Chapter 186 Hepatitis C
- Chapter 187 HIV and renal disease
- Chapter 188 Hantaviral infections
- Chapter 189 Dengue and other viral haemorrhagic fevers
- Chapter 190 Yellow fever, severe acute respiratory syndrome virus, and H1N1 influenza infections
- Chapter 191 Leptospirosis
- Chapter 192 Syphilis
- Chapter 193 Rickettsiosis
- Chapter 194 Schistosomiasis
- Chapter 195 Nematode infections
- Chapter 196 Mycobacterial infections: tuberculosis
- Chapter 197 Mycobacterial infections: leprosy and environmental mycobacteria
- Chapter 198 Renal involvement in other infections: diarrhoeal diseases, salmonella, melioidosis, and pregnancy
- Section 9 The patient with urinary stone disease
- Chapter 199 Epidemiology of nephrolithiasis
- Chapter 200 Approach to the patient with kidney stones
- Chapter 201 Calcium stones
- Chapter 202 Uric acid stones
- Chapter 203 Cystine stones
- Chapter 204 Cell biology of nephrocalcinosis/nephrolithiasis
- Chapter 205 Medical management of nephrocalcinosis and nephrolithiasis
- Chapter 206 Imaging and interventional treatment: urolithiasis from the surgeon’s point of view
- Section 10 The Patient with Hypertension
- Chapter 207 The structure and function of renal blood vessels
- Chapter 208 Regulation of vasomotor tone in the afferent and efferent arterioles
- Chapter 209 Tubuloglomerular feedback, renal autoregulation, and renal protection
- Chapter 210 The kidney and control of blood pressure
- Chapter 211 The effect of hypertension on renal vasculature and structure
- Chapter 212 Ischaemic nephropathy
- Chapter 213 Renal artery stenosis: clinical features and diagnosis
- Chapter 214 Renal artery stenosis: diagnosis
- Chapter 215 Renal artery stenosis: management and outcome
- Chapter 216 Malignant hypertension
- Chapter 217 Resistant hypertension
- Chapter 218 The hypertensive child
- Chapter 219 Treatment of hypertension in children
- Section 11 The patient with acute kidney injury (and critical care nephrology)
- Chapter 220 Definitions, classification, epidemiology, and risk factors of acute kidney injury
- Chapter 221 Pathophysiology of acute kidney injury
- Chapter 222 Clinical approach to the patient with acute kidney injury: diagnosis and differential diagnosis
- Chapter 223 The role of novel biomarkers in acute kidney injury
- Chapter 224 Prevention of acute kidney injury: evaluation of important risk factors of acute kidney injury
- Chapter 225 Prevention of acute kidney injury: non-pharmacological strategies
- Chapter 226 Prevention of acute kidney injury: pharmacological strategies
- Chapter 227 Prevention of acute kidney injury: drug- and nephrotoxin-induced acute kidney injury
- Chapter 228 Non-dialytic management of the patient with acute kidney injury
- Chapter 229 Fluid overload in acute kidney injury
- Chapter 230 Electrolyte and acid–base disorders in AKI
- Chapter 231 Coagulation disturbances in acute kidney injury
- Chapter 232 Renal replacement therapy in the patient with acute kidney injury: overview
- Chapter 233 Intermittent acute renal replacement therapy
- Chapter 234 Continuous renal replacement therapy
- Chapter 235 Peritoneal dialysis in acute kidney injury
- Chapter 236 Scoring systems in acute kidney injury patients
- Chapter 237 Overall outcomes of acute kidney injury
- Chapter 238 Renal outcomes of acute kidney injury
- Chapter 239 Acute kidney injury in children
- Chapter 240 Acute kidney injury in the elderly
- Chapter 241 Acute kidney injury in the tropics
- Chapter 242 Acute kidney injury and hantavirus disease
- Chapter 243 Community-acquired pneumonia and acute kidney injury
- Chapter 244 Acute kidney injury in severe sepsis
- Chapter 245 Cardiovascular surgery and acute kidney injury
- Chapter 246 Contrast-induced acute kidney injury
- Chapter 247 Renal failure in cirrhosis: pathogenesis, diagnosis, and treatment
- Chapter 248 Acute kidney injury in heart failure
- Chapter 249 Acute kidney injury in pulmonary diseases
- Chapter 250 Acute kidney injury in pregnancy
- Chapter 251 Acute kidney injury in the cancer patient
- Chapter 252 Acute kidney injury in polytrauma and rhabdomyolysis
- Chapter 253 Acute kidney injury in patients with severe burn injury
- Section 12 The patient on dialysis
- Chapter 254 Overview of uraemic toxins
- Chapter 255 Haemodialysis: overview
- Chapter 256 Haemodialysis: vascular access
- Chapter 257 Haemodialysis: principles
- Chapter 258 Haemodialysis: prescription and assessment of adequacy
- Chapter 259 Haemodialysis: acute complications
- Chapter 260 Haemofiltration and haemodiafiltration
- Chapter 261 Dialysis withdrawal and palliative care
- Chapter 262 Frequent haemodialysis
- Chapter 263 Peritoneal dialysis: overview
- Chapter 264 Peritoneal dialysis: principles and peritoneal physiology
- Chapter 265 Peritoneal dialysis: adequacy and prescription management
- Chapter 266 Peritoneal dialysis: non-infectious complications
- Chapter 267 Overview of dialysis patient management and future directions
- Chapter 268 Cardiovascular complications in end-stage renal disease patients: pathophysiological aspects
- Chapter 269 Bacterial and fungal infections in patients on haemodialysis
- Chapter 270 Bacterial and fungal infections in patients on peritoneal dialysis
- Chapter 271 Viral infections in patients on dialysis
- Chapter 272 Cognitive function, depression, and psychosocial adaptation
- Chapter 273 Volume assessment and management in dialysis
- Chapter 274 Nutritional screening and nutritional management in dialysis patients
- Section 13 The transplant patient
- Chapter 275 The evolution of kidney transplantation
- Chapter 276 Pre-transplant assessment of the recipient
- Chapter 277 Organ donation
- Chapter 278 Donor and recipient kidney transplantation surgery
- Chapter 279 Immunology, sensitization, and histocompatibility
- Chapter 280 Immediate post-transplant care and surgical complications
- Chapter 281 Immunosuppression: drugs and protocols
- Chapter 282 Renal transplant imaging
- Chapter 283 Rejection
- Chapter 284 Infection: prophylaxis, diagnosis, and management
- Chapter 285 Cardiovascular disease: prophylaxis, diagnosis, and management
- Chapter 286 Chronic allograft dysfunction
- Chapter 287 Cancer after kidney transplantation
- Chapter 288 Metabolic bone disease after renal transplantation
- Chapter 289 Recurrent renal disease: prophylaxis, diagnosis, and management
- Chapter 290 Paediatric renal transplantation
- Section 14 Renal disease at different stages of life (infancy, adolescence, pregnancy, old age)
- Chapter 291 Growth and development
- Chapter 292 The adolescent with renal disease: transition to adult services
- Chapter 293 Contraception in patients with kidney disease
- Chapter 294 Pregnancy and renal physiology
- Chapter 295 Pregnancy in patients with chronic kidney disease and on dialysis
- Chapter 296 Pre-eclampsia and related disorders
- Chapter 297 Acute kidney injury in pregnancy
- Chapter 298 Specific renal conditions in pregnancy
- Chapter 299 Pregnancy after renal transplantation
- Chapter 300 The kidney in ageing: biology, anatomy, physiology, and clinical relevance
- Section 15 The patient with genetic renal disease
- Chapter 301 Ethical aspects of genetic testing
- Chapter 302 Antenatal diagnosis and pre-implantation genetic testing
- Chapter 303 The molecular basis of ciliopathies and cyst formation
- Chapter 304 The adult with renal cysts
- Chapter 305 The child with renal cysts
- Chapter 306 Autosomal dominant polycystic kidney disease: overview
- Chapter 307 Autosomal dominant polycystic kidney disease: clinical features
- Chapter 308 Autosomal dominant polycystic kidney disease: diagnosis
- Chapter 309 Autosomal dominant polycystic kidney disease management
- Chapter 310 Management of intracranial aneurysms
- Chapter 311 Management of cystic liver disease
- Chapter 312 Autosomal dominant polycystic kidney disease in children and young adults
- Chapter 313 Autosomal recessive polycystic kidney disease
- Chapter 314 Bardet–Biedl syndrome and other ciliopathies
- Chapter 315 Hepatocyte nuclear factor-1B
- Chapter 316 Nephronophthisis and medullary cystic kidney disease: overview
- Chapter 317 Nephronophthisis
- Chapter 318 Autosomal dominant tubule-interstitial kidney disease, including medullary cystic disease
- Chapter 319 Oral-facial-digital type 1 syndrome
- Chapter 320 The molecular basis of glomerular basement membrane disorders
- Chapter 321 Alport syndrome: overview
- Chapter 322 Alport syndrome: clinical features
- Chapter 323 Alport syndrome: diagnosis
- Chapter 324 Alport syndrome: management
- Chapter 325 Thin glomerular basement membrane nephropathy and other collagenopathies
- Chapter 326 Nail patella syndrome
- Chapter 327 Molecular basis of nephrotic syndrome
- Chapter 328 Molecular basis of renal tumour syndromes
- Chapter 329 WT1 and its disorders
- Chapter 330 Tuberous sclerosis complex renal disease
- Chapter 331 Hypoxia-inducible factor and renal disorders
- Chapter 332 Von Hippel–Lindau disease
- Chapter 333 Molecular basis of complement-mediated renal disease
- Chapter 334 Inherited metabolic diseases and the kidney
- Chapter 335 Fabry disease: overview and pathophysiology
- Chapter 336 Fabry disease: clinical features
- Chapter 337 Fabry disease: diagnosis
- Chapter 338 Fabry disease: management and outcome
- Chapter 339 Cystinosis
- Chapter 340 Mitochondrial diseases and the kidney
- Chapter 341 APOL1 and renal disease
- Chapter 342 MYH9 and renal disease
- Section 16 The patient with structural and congenital abnormalities
- Chapter 343 Human kidney development
- Chapter 344 Kidney stem cells
- Chapter 345 Anatomical types of congenital anomalies: overview of obstruction
- Chapter 346 Renal agenesis
- Chapter 347 Renal dysplasia
- Chapter 348 Renal hypoplasia
- Chapter 349 Normal variation in nephron numbers
- Chapter 350 Renal tubular dysgenesis
- Chapter 351 Congenital solitary functioning kidney
- Chapter 352 Duplex, ectopic, and horseshoe kidneys
- Chapter 353 Pelviureteric junction obstruction and megaureter in children
- Chapter 354 Posterior urethral valves
- Chapter 355 Primary vesicoureteric reflux and reflux nephropathy
- Chapter 356 The patient with urinary tract obstruction
- Chapter 357 Retroperitoneal fibrosis
- Chapter 358 Branchio-oto-renal syndrome
- Chapter 359 Townes–Brocks syndrome
- Chapter 360 Renal coloboma syndrome
- Chapter 361 Ante- and postnatal imaging to diagnose human kidney malformations
- Section 17 Drugs and renal disease
- Section 18 Nephrology in the future
- End Matter