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A brief history of ankylosing spondylitis 

A brief history of ankylosing spondylitis
A brief history of ankylosing spondylitis
Axial Spondyloarthritis (Oxford Rheumatology Library)

Stefan Siebert

, Sengupta Raj

, and Alexander Tsoukas


The history of ankylosing spondylitis (AS) dates back to the discovery of skeletons with characteristic spinal changes. The disease was further defined by correlating pathological and clinical features, and the development of clinical radiology. Subsequent epidemiology and familial studies highlighted the association with other related conditions as part of the spondyloarthritides. The discovery of HLA-B27 confirmed this association. Over the past two decades, genome-wide association studies, and advances in imaging and immunology have yielded dramatic insights into the disease and the development of highly effective therapies.

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