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Metabolic syndrome 

Metabolic syndrome
Metabolic syndrome
Oxford Textbook of Geriatric Medicine (3 edn)

Stefania Maggi

and Gaetano Crepaldi


Two of the major determinants of rising healthcare costs in Western society are represented by population ageing, which is accompanied by a parallel increase in age-associated diseases and disabilities, as well as by obesity and its related comorbidities. Many studies have shown that selected risk factors such as impaired glucose tolerance, atherogenic dyslipidemia, and hypertension co-occur to a greater degree than that expected by chance alone in obese individuals (especially in those with central obesity). Their co-occurrence has been defined as ‘metabolic syndrome’, a multifactorial disease of substantial heterogeneity, a major risk factor for type 2 diabetes mellitus, atherosclerotic cardiovascular disease (CVD) and, in the older population, also for cancer, cognitive decline, functional dependence, depression, low quality of life, and mortality. Identifying and treating metabolic syndrome (MS) is thus of vital importance because it could lead to a significant decrease in the burden of morbidity and mortality in older patients.

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