Autoimmune hepatitis (AIH) 386

Autoimmune hepatitis/sclerosing cholangitis overlap syndrome (ASC) 388

In paediatrics, two forms of autoimmune liver disease are recognized:

• Autoimmune hepatitis (AIH)

• AIH/sclerosing cholangitis overlap syndrome (autoimmune sclerosing cholangitis, ASC).

• Progressive inflammatory liver disorder, preferentially affecting females, characterized serologically by high levels of transaminases and IgG and presence of autoantibodies, and histologically by interface hepatitis in the absence of a known aetiology....