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Drug-induced liver injury 

Drug-induced liver injury
Chapter:
Drug-induced liver injury
Source:
Paediatric Gastroenterology, Hepatology and Nutrition (Oxford Specialist Handbooks in Paediatrics) (1 ed.)
Author(s):

R. Mark Beattie

, Anil Dhawan

, and John W.L. Puntis

DOI:
10.1093/med/9780198569862.003.0052

Epidemiology 374

Pathophysiology 374

Herbal drugs and alternative medicines 377

Risk factors 377

Clinical features 378

Investigation 379

Management 380

Drug induced liver injury (DILI) is a variable and complex diagnosis of exclusion, as it can present in different ways. Because of the liver's central role in drug metabolism, most prescribed drugs can cause liver injury. Liver damage can occur through drugs in a predictable, intrinsic dose-related way or in a unpredictable, idiosyncratic dose-unrelated fashion....

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