Genetics 358

Clinical features 358

Differential diagnosis 359

Investigations 359

Management: multidisciplinary approach 360

Prognosis 360

Alagille syndrome is a complex multisystem disorder with a prevalence of 1:40 000–1:100 000, characterized by hepatic, cardiac, renal, and ocular involvement. At least three of the following five major criteria are required to establish the diagnosis: ...