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Cerebral Hemorrhage and High INR 

Cerebral Hemorrhage and High INR
Cerebral Hemorrhage and High INR
Neurocritical Care (2 ed.)

Eelco F. M. Wijdicks

, Alejandro A. Rabinstein

, Sara E. Hocker

, and Jennifer E. Fugate


Anticoagulation-associated cerebral hemorrhage often results in expansion and worsening of the clinical condition. Early reversal of an anticoagulant is key to reduce the hemorrhage volume. Traditionally, it involves administration of fresh frozen plasma and vitamin K, but this chapter discusses more current pharmacological approaches. One is use of prothrombin complex concentrates, which are the most effective way to reverse warfarin. Another is use of protamine, which reverses unfractionated heparin. Correction of other types of acquired coagulopathies is also mentioned in the chapter.

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