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Seizures 

Seizures
Chapter:
Seizures
Source:
Introduction to Clinical Neurology (5 ed.)
Author(s):

Douglas J. Gelb

DOI:
10.1093/med/9780190467197.003.0005

The clinical manifestations of a seizure depend on where the abnormal neuronal activity starts (the seizure focus) and how it spreads. Some seizures have no apparent focus—from the very beginning, they seem to involve neuronal networks spread throughout both cerebral hemispheres, called general seizures. Patients with seizures do not necessarily have epilepsy. Epilepsy represents a failure of the protective mechanisms that usually inhibit large groups of neurons from engaging in repetitive, entrained activity. Patients who present with seizures can be grouped into three broad categories: (1) those whose seizures are precipitated by clearly identified systemic factors, (2) those with epilepsy, and (3) those who experience a single unprovoked seizure with no evidence of predisposition to recurrent seizures.

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