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Diabetic Peripheral Neuropathy 

Diabetic Peripheral Neuropathy
Chapter:
Diabetic Peripheral Neuropathy
Source:
Neuropathic Pain: A Case-Based Approach to Practical Management
Author(s):

Maximilian Hsia-Kiung

DOI:
10.1093/med/9780190298357.003.0016

Diabetic peripheral neuropathy (DPN) is the most common cause of peripheral neuropathy in the developed world and one of the most common causes of neuropathic pain encountered, affecting about 50% of patients with type 1 or type 2 diabetes. The diagnosis of DPN is often made by self-reported symptoms, although a validated screening tool such as the Michigan Neuropathy Screening Instrument (MNSI) has been shown to be more effective. A phenomenon called insulin neuritis can also occur when blood glucose control is rapid or the patient experiences significant weight loss. Treatment of painful symptoms associated with DPN consists of prevention of symptom progression through glycemic control, oral medications such as tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors, topical medications, and, in some cases, neuromodulation using spinal cord stimulators.

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