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Psychoneuroimmunology of Post-Traumatic Stress Disorder 

Psychoneuroimmunology of Post-Traumatic Stress Disorder
Psychoneuroimmunology of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder

Rebecca Hannah Bind

, and Carmine M. Pariante


This chapter reviews the evidence linking post-traumatic stress disorder (PTSD) with changes in immune function. The chapter starts with a brief explanation of the components of the immune system, including cytokines, and of the mechanisms linking psychological and psychiatric phenomena with changes in immune function (i.e., psychoneuroimmunology). Specific studies on PTSD are then described, including the potential neurobiological and health consequences of these immune changes and, finally, the effects of PTSD treatment on both symptomology and the immune system. While there is a consistent pattern of findings indicating increased immune activation in this condition, there is a paucity of research on the immunological correlates of PTSD, especially compared with the large number of immunological studies on depression and other psychiatric disorders.

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