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Ovarian Tumor Microenvironment and Innate Immune Recognition 

Ovarian Tumor Microenvironment and Innate Immune Recognition
Chapter:
Ovarian Tumor Microenvironment and Innate Immune Recognition
Source:
Ovarian Cancer Immunotherapy
Author(s):

Jocelyn Reader

, Sarah Lynam

, Amy Harper

, Gautam Rao

, Maya Matheny

, and Dana M. Roque

DOI:
10.1093/med/9780190248208.003.0004

Ovarian adenocarcinoma is typified by detection at late stages with dissemination of cancer cells into the peritoneal cavity and frequent acquisition of chemoresistance. A number of studies show the importance of the tumor microenvironment and innate immune recognition in tumor progression. Ovarian cancer cells can regulate the composition of their stroma to promote the formation of ascitic fluid rich in cytokines and bioactive lipids such as PGE2, and to stimulate the differentiation of stromal cells into a pro-tumoral phenotype. In response, cancer-associated fibroblasts, cancer-associated mesenchymal stem cells, tumor-associated macrophages, and other peritoneal cells can act through direct and indirect mechanisms to regulate tumor growth, chemoresistance via alteration of class III β‎ tubulin, angiogenesis and dissemination. This chapter deciphers the current knowledge about the role of stromal cells, associated secreted factors, and the immune system on tumor progression. This suggests that targeting the microenvironment holds great potential to improve the prognosis of patients with ovarian adenocarcinoma.

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