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Ovarian Cancer Immunity: How Does Immune Suppression Grow Cancer? 

Ovarian Cancer Immunity: How Does Immune Suppression Grow Cancer?
Chapter:
Ovarian Cancer Immunity: How Does Immune Suppression Grow Cancer?
Source:
Ovarian Cancer Immunotherapy
Author(s):

Vincent Lavoué

, Patrick Legembre

, Jean Levêque

, Fabrice Foucher

, Sébastien Henno

, and Florian Cabillic

DOI:
10.1093/med/9780190248208.003.0003

Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the past three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an anti-tumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This chapter focuses on the immune response and immune suppression in EOC.

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