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Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy 

Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy
Chapter:
Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy
Source:
Ovarian Cancer Immunotherapy
Author(s):

Anca Maria Cimpean

, Andreea Adriana Jitariu

, and Marius Raica

DOI:
10.1093/med/9780190248208.003.0011

Ovarian cancer remains one of the most aggressive and difficult to manage malignancies regarding evaluation and therapeutic options. The high mortality persists despite extensive research in the field. Current conventional chemotherapy does not improve disease-free survival and does not decrease recurrences amongst patients. This calls for a stringent reconsideration of the drugs selection, focused on the most targeted strategies and personalization of the therapy. Targeted agents against growth factors and their corresponding receptors are already approved as first- or second-line neoadjuvant therapy with controversial results. This chapter critically discusses the role of growth factors as vascular endothelial growth factor, fibroblast growth factors, or platelet-derived growth factors and their corresponding receptors in the pathogenesis, progression, and selection of therapeutic strategies. Other growth factors, such as nerve growth factor or endocrine gland derived growth factor, seem to have a strong involvement in ovarian carcinogenesis but their actual impact is not fully understood.

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