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Substance Use Disorders 

Substance Use Disorders
Substance Use Disorders
Mayo Clinic Neurology Board Review

Tamara J. Dolenc


Substance dependence is a chronic, relapsing illness. Episodes of intoxication are common, along with significant medical and social consequences. Substance dependence is accompanied by loss of control over the amount used, continued use despite negative consequences, preoccupation with use, and dysphoria during abstinence. In heavy and long-term users, abrupt cessation or reduction in substance use results in withdrawal syndrome. Risk of substance dependence is influenced by genetic, psychosocial, and environmental factors. Patients with substance use disorders come from all age groups and from all ethnic, cultural, and socioeconomic backgrounds.

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