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Cognitive Enhancement in Traumatic Brain Injury 

Cognitive Enhancement in Traumatic Brain Injury
Cognitive Enhancement in Traumatic Brain Injury
Cognitive Enhancement in CNS Disorders and Beyond

Tessa Hart


Traumatic brain injury (TBI) is a prevalent source of disability. This chapter reviews the major approaches to remediation of cognitive dysfunction following TBI, in both the early and post-acute phases of recovery. Pharmacologic and behavioral treatments are discussed, focusing on the three major areas of cognition affected by TBI: attention, memory, and executive function. Trials of pharmacologic treatments, especially neuroprotective agents, have resulted in few treatment guidelines, probably due to the heterogeneous pathophysiology of TBI. Among behavioral treatments, both restorative and compensatory approaches are presented. Most of the available evidence favors compensatory treatments, in which patients are taught alternative strategies and/or changes are made in the social/physical environments to facilitate everyday functioning. Despite methodologic challenges and limitations in treatment definition that make comparisons across studies difficult, cognitive rehabilitation for TBI is increasingly viewed as a vital component of the effort to restore maximal independence at home and in society.

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