Page of

Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins 

Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins
Chapter:
Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins
Source:
Neuroglia (2 ed.)
Author(s):

Klaus-Armin Nave

and Ueli Suter

DOI:
10.1093/acprof:oso/9780195152227.003.0043

This chapter presents an overview of mutations in the mouse that have improved our understanding of structural myelin proteins. Mouse genetics, in combination with molecular cell biology and morphology, has provide important insights into the process of myelination. For some myelin proteins, a specific function in the architecture of myelin can be demonstrated. In other cases, a more complex picture has emerged from overlapping loss-of-function and aberrant gain-of-function effects. The latter is a recurrent feature of natural point mutations with autosomal dominant (or X-linked recessive) inheritance.

Sign In

Copyright © 2020. All rights reserved.