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Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells 

Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells
Chapter:
Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells
Source:
Neuroglia (2 ed.)
Author(s):

Ulrich Dirnagl

and Josef Priller

DOI:
10.1093/acprof:oso/9780195152227.003.0041

This chapter begins by looking at the principal mechanisms of ischemic damage and identifies what is known about the specific contribution of glial cells. It then changes the perspective from affected tissue to single cells and reassesses the specific contribution of the glial cell types (astroglia, microglia, oligodendrocytes) in this process. Glial cells are major contributors to damage, as well as to endogenous protection and repair after stroke. The fact that the same cell types partake in damaging as well as protective signaling precludes simple therapeutic approaches aimed at blocking or inducing the activities of glial cells. Nevertheless, the recent appreciation of the high susceptibility of oligodendrocytes to AMPA-mediated cell death and the successful pilot trial on the use of EPO in stroke in humans are examples of the outstanding clinical relevance of glial mechanisms in stroke.

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