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Second Messenger Systems 

Second Messenger Systems
Second Messenger Systems
Neuroglia (2 ed.)

Sean Murphy

and Brian R. Pearce


This chapter focuses on recent developments in (predominantly astro-) glial second messenger pathways, particularly those involved in intracellular Ca2+ signaling. It illustrates signaling cascades in glia by reference to the regulation of expression and activity of the nitric oxide synthases (NOS). The product of NOS activity, nitric oxide (NO), then interacts with numerous other molecules, including cyclooxygenase (COX)-2. The chapter draws attention to the evidence for assemblies of signaling molecules. Compared with highly polarized endothelial cells and neurons, little attention has been paid to such compartmentation within glia.

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