Neuroglia
Helmut Kettenmann and Bruce R. Ransom
Print publication date: Oct 2004
ISBN: 9780195152227
Publisher: Oxford University Press
Abstract
Reflecting the dramatic advances in the field since the first edition was published 10 years ago, this resource is the only comprehensive reference on glial cells. The majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. This second edition covers the entire field of glial research from the basic molecular and cellular structure of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease and multiple sclerosis. It includes chapters on transmitter release by exocytosis from glia, glia-derived stem cells, glia and synaptic transmission, glia and axon guidance, mechanisms of glial injury, and the roles of glia in different diseases.
Table of Contents
- Front Matter
- 1 The Concept of Neuroglia: A Historical Perspective
- I
Properties of Neuroglial Cells - 2 Astrocytes and Ependymal Glia
- 3 Structure and Function of Oligodendrocytes
- 4 Schwann Cells and Myelin
- 5 Microglial Cells
- 6 Lineages of Astrocytes and Oligodendrocytes
- 7 The Schwann Cell Lineage
- 8 The Role of Neurogenic Astroglial Cells in the Developing and Adult Central Nervous System
- 9 Voltage-Activated Ion Channels in Glial Cells
- 10 Receptors for Neurotransmitters and Hormones
- 11 Cytokine and Chemokine Receptors and Signaling
- 12 Mechanisms of Solute Transport in Glia
- 13 Gap Junctions and Hemichannels
- 14 Quantal Release of Transmitter: Not Only from Neurons but from Aastrocytes as Well?
- 15 Enzymes of Carbohydrate and Energy Metabolism
- 16 Second Messenger Systems
- 17 Intracellular Calcium Control Mechanisms in Glia
- 18 Cytoskeletal Proteins in Astroglia
- II
Functions of Neuroglial Cells - 19 Molecular Biology of Myelination
- 20 Factors Controlling Myelin Formation
- 21 Myelin Function and Saltatory Conduction
- 22 Cytokine Production
- 23 Interaction of Glial Cells with Monocytes
- 24 Antigen Processing, Presentation, and T Cell Interaction
- 25 The Role of Glia in the Formation and Function of the Blood–Brain Barrier
- 26 Extracellular Potassium and pH: Homeostasis and Signaling
- 27 Astrocyte Neurotransmitter Uptake
- 28 Glia and Synaptic Transmission
- 29 The Central Role of Astrocytes in Neuroenergetics
- 30 Growth Factors for Neurons Provided by Macroglial Cells
- 31 Radial Glial Cells: Scaffolding for Cortical Development and Evolution
- 32 Axon Guidance
- III
Disease and Neuroglial Cells - 33 Astrocyte Injury
- 34 Oligodendrocyte and Schwann Cell Injury
- 35 Response of Microglia to Brain Injury
- 36 Axonal Regeneration in the Peripheral Nervous System of Mammals
- 37 Axonal Regeneration in the Central Nervous System of Mammals
- 38 Transplantation of Myelin-Forming Cells
- 39 Multiple Sclerosis
- 40 Human Immunodeficiency Virus Infection of the Central Nervous System
- 41 Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells
- 42 Gliomas
- 43 Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins
- 44 Astrocytic Swelling in Neuropathology
- 45 The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease
- 46 Peripheral Neuropathy and the Schwann Cell
- 47 Reaction of Glial Cells in Infectious Disorders of the Central Nervous System
- End Matter
