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Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research, and is now an intense growth area in behavioral and educational treatments. This resource provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders, including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology.Less

In this resource, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify both the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. Based upon these discussions, it then integrates these diverse considerations to develop a specific neurophysiological model of bipolar disorder. Less

The fifth edition finds the text of The Central Nervous System thoroughly updated and revised to better equip students with essential information in the field of clinical neuroscience. This text is revised to reflect new information as well as understanding of student needs for critical thinking. This text seamlessly integrates data from all fields of neuroscience as well as clinical neurology and psychology and presents the functional properties of clinically-relevant disorders by incorporating data from molecular biology to clinical neurology. While most neurological textbooks are cobbled together by multiple authors on a variety of topics within the field, Dr. Brodal pulls together a cohesive and comprehensive guide to neuroscience. This book reflects Dr. Brodal's concise and easy-to-read style, encouraging reflection and critical thinking in established facts and scientific conjecture. This is the perfect reference for medical, graduate, and undergraduate students alike. Key Features of the Fifth Edition include chapters knit together by numerous cross-references and explanations, helping the reader to connect data; carefully selected full color line drawings of the complexities of the nervous system; extensive use of text-boxes provides in-depth material without disturbing the flow of reading; and crucial lists of references for further reading. Less

Handbook of Brain Microcircuits comprehensively illustrates how the concept of microcircuits is emerging as one of the major organizing principles of the nervous system. A major challenge in neuroscience is to synthesize multidisciplinary data to give insight into brain function. The organization of neurons into microcircuits has emerged as a main theme to accomplish this. The wiring diagrams for these microcircuits are increasingly serving as canonical representations that enhance understanding of the basic functional organization of a region, focus experimental and theoretical tests of its functional properties, and facilitate comparisons with other regions.Less

No other neurological condition allows the same opportunities for intracranial electrophysiological study of the human brain as epilepsy does. What ensues is exponentially expanding knowledge of the human epileptic brain, as well as windows into the physiology of the normal human brain itself. In Invasive Studies of the Epileptic Human Brain, some of the most renowned epilepsy experts of the twentieth and twenty-first centuries provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of human brain function, and approaches to the use of invasive electroencephalography in a variety of clinical situations. It is an essential read for neurologists and neurosurgeons involved in epilepsy surgery, as well as neuroscientists and clinician researchers interested in the epileptic brain. It is organized in an easily readable series of chapters that will also appeal to trainees and students of these fields. Many of the chapters are brilliantly illustrated with case studies, and each provides an intuitively comprehensive approach to invasive brain studies. A burgeoning, worldwide, interest in stereotactic electroencephalography (SEEG), the use of sophisticated, cutting edge, multimodal imaging and other ancillary techniques, and the increasing complexity of epilepsy surgery cases makes this a timely publication, and a likely classic.Less

Written and designed to provide comprehensive, easily accessible advice for all healthcare professionals involved in the care of patients with this challenging condition, this resource addresses the entire care pathway from presentation to diagnosis to symptom management and end of life issues.Less

Multiple Sclerosis Care - A Practical Manual is a concise and easy to use reference source for all aspects of care in the management and understanding of Multiple Sclerosis (MS). Teams of doctors, nurses, physio and occupational therapists, social workers and other care workers will find it an accessible, useful and handy resource. Less

Reflecting the dramatic advances in the field since the first edition was published 10 years ago, this resource is the only comprehensive reference on glial cells. The majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. This second edition covers the entire field of glial research from the basic molecular and cellular structure of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease and multiple sclerosis. It includes chapters on transmitter release by exocytosis from glia, glia-derived stem cells, glia and synaptic transmission, glia and axon guidance, mechanisms of glial injury, and the roles of glia in different diseases.Less

This resource is the long-awaited new revision of the most highly regarded reference volume on glial cells, and has been completely revised, greatly enlarged, and enhanced with full color figures throughout. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. With more than 20 new chapters it addresses the massive growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function.Less

A practical resource for anyone caring for people with progressive disability due to muscle wasting conditions

The Oxford Textbook of Clinical and Biomedical Disorders of the Skeleton provides an up-to-date account of the ‘classic’ and ‘new’ metabolic disorders of the skeleton, and deals with their causes, clinical aspects, and treatment. Bone biology and investigation precede chapters on osteoporosis, osteomalacia and rickets, parathyroid bone disease, Paget disease, and the effects of malignancy on the skeleton. The ‘new’ metabolic bone disorders follow, with chapters on osteogenesis imperfecta, skeletal dysplasias, osteopetrosis, and osteosclerosis, Marfan syndrome, Ehlers–Danlos syndrome, enzyme defects and the skeleton, fibrous dysplasia, fibrogenesis imperfecta ossium, and ectopic mineralization. In all the latest known molecular causes are discussed and personal experiences of the disorders are described.Less

This resource is a newly organized and thoroughly updated volume of nine different sections, including anatomy and neuropharmacology, development, systems and models, fundamental cognitive mechanisms, social behavior, clinical neuropsychology, aging, psychiatric disorders, and rehabilitation. It reflects both an increase in the combined knowledge about frontal lobe functioning through new imaging technologies, as well as the expansion of the field as a whole to include new topics such as social neuroscienceLess