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Contents
- Front Matter
- Section 1 Clinical presentations of rheumatic disease in different age groups
- Chapter 1 The child patientLori B. Tucker
- Chapter 2 Young people and developmentally appropriate transitional care in rheumatologyJanet E. McDonagh and Helena Gleeson
- Chapter 3 The adult patientPaul Thompson
- Chapter 4 The elderly patientFraser Birrell and Janice O’Connell
- Chapter 5 Principles of clinical examination in childrenSharmila Jandial and Helen Foster
- Chapter 6 Principles of clinical examination in adultsLesley Kay
- Section 2 Common clinical presentations of rheumatic disease
- Chapter 7 Monoarticular diseaseMark Lillicrap and Shazia Abdullah
- Chapter 8 Oligoarticular diseaseAndrew Keat
- Chapter 9 Polyarticular diseaseAde Adebajo and Lisa Dunkley
- Chapter 10 The systemically ill patientJoanna Robson, Anna Mistry, Kuljeet Bhamra, Stefan Kluzek, and Raashid Luqmani
- Chapter 11 Spinal painKarl Gaffney and Louise Hamilton
- Chapter 12 Pain and fatigueCandy McCabe, Richard Haigh, Helen Cohen, and Sarah Hewlett
- Chapter 13 The limping childYukiko Kimura and Taunton R. Southwood
- Chapter 14 The systemically unwell childAthimalaipet V. Ramanan and Jonathan D. Akikusa
- Chapter 15 Primary care presentationElspeth Wise
- Section 3 Clinical presentations: views from different perspectives
- Chapter 16 Obstetrics and pregnancyMonika Østensen, Radboud Dolhain, and Guillermo Ruiz-Irastorza
- Chapter 17 SkinChristopher Griffiths and Amy Foulkes
- Chapter 18 Nervous systemAndrew Graham and Clare Galton
- Chapter 19 Cardiovascular systemJ. Gerry Coghlan and Benjamin E. Schreiber
- Chapter 20 Respiratory systemRachel K. Hoyles and Athol U. Wells
- Chapter 21 Gastrointestinal systemGerhard Rogler
- Chapter 22 Neuroendocrine system and chronic autoimmune rheumatic diseasesRainer H. Straub
- Chapter 23 MalignancyJennifer Hamilton and Clive Kelly
- Chapter 24 The eyeHarry Petrushkin, Duncan Rogers and Miles Stanford
- Chapter 25 The kidneyMark Little and Alan Salama
- Chapter 26 PsychologyHayley McBain, Sophie Cleanthous, and Stanton Newman
- Section 4 The impact of rheumatic disease
- Chapter 27 Epidemiology and the rheumatic diseasesDeborah P. M. Symmons
- Chapter 28 Assessment of rheumatic diseasePiet van Riel
- Chapter 29 OutcomesDavid L. Scott
- Chapter 30 Design of clinical trials in rheumatologyVibeke Strand, Jeremy Sokolove, and Alvina D. Chu
- Chapter 31 Health economicsSonja Merkesdal and Wilfried Mau
- Chapter 32 Comorbidities of rheumatic diseaseTuulikki Sokka, Kari Puolakka, and Carl Turesson
- Chapter 33 Social aspects (work)Ross Wilkie
- Chapter 34 Biologics registriesDavid Isenberg and Angela Zink
- Chapter 35 Outcomes of paediatric rheumatic diseaseKirsten Minden
- Chapter 36 Assessment of paediatric rheumatic diseaseLoren A. Matheson and Ciarán M. Duffy
- Section 5 Genetics and environment
- Chapter 37 Basics of geneticsAnne Barton
- Chapter 38 EnvironmentChristopher R. Holroyd, Nicholas C. Harvey, Mark H. Edwards, and Cyrus Cooper
- Chapter 39 EpigeneticsSteffen Gay and Michel Neidhart
- Chapter 40 Genetics of rheumatoid arthritisSteve Eyre, Gisela Orozco, and Jane Worthington
- Chapter 41 Genetics of spondyloarthropathiesMatthew Brown
- Chapter 42 Genetics of connective tissue diseasesMyles Lewis and Tim Vyse
- Chapter 43 Genetics of juvenile rheumatic diseasesElena Lopez-Isac, Anne Hinks, and Wendy Thomson
- Chapter 44 Genetics of osteoarthritisAlex MacGregor, Ana Valdes, and Frances M. K. Williams
- Chapter 45 Genetics of chronic musculoskeletal painNisha Nair, Kate L. Holliday, Wendy Thomson, and John McBeth
- Section 6 Tissues in health and disease
- Chapter 46 Normal functional anatomy of jointsMike Benjamin and Dennis McGonagle
- Chapter 47 Measuring movement and gaitLindsey Hooper, Mark Taylor, and Christopher Edwards
- Chapter 48 Innate vs acquired immunityReinhard E. Voll and Barbara M. Bröker
- Chapter 49 Cellular side of acquired immunity (T cells)Assia Eljaafari and Pierre Miossec
- Chapter 50 Cellular side of acquired immunity (B cells)Thomas Dörner and Peter E. Lipsky
- Chapter 51 Fibroblasts and mesenchymal cellsAndrew Filer, Maria Juarez, and Christopher Buckley
- Chapter 52 Synovial pathologyCostantino Pitzalis, Frances Humby, and Michael P. Seed
- Chapter 53 Bone turnoverGeorg Schett
- Chapter 54 EnthesitisMartin Rudwaleit
- Chapter 55 Skeletal muscle physiology and damageRobert Dinser(), Ulf Müller-Ladner
- Chapter 56 Joints and Connective tissue—structure and functionThomas Pap, Adelheid Korb-Pap, Dr Christine Hartmann and Jessica Bertrand
- Chapter 57 Vascular biologyClare Thornton and Justin Mason
- Chapter 58 Acute-phase responses and adipocytokinesElena Neumann, Klaus Frommer, and Ulf Müller-Ladner
- Chapter 59 Pain neurophysiologyHans-Georg Schaible and Rainer H. Straub
- Chapter 60 Pathogenesis of juvenile idiopathic arthritisDavid Bending, Kiran Nistala, Lucy R. Wedderburn and Dr Elizabeth C. Rosser
- Section 7 Practical investigation of rheumatic disease
- Chapter 61 HaematologyPatrick Kesteven
- Chapter 62 Biochemical investigation of rheumatic diseasesBerenice Lopez and Patrick J. Twomey
- Chapter 63 Autoimmune serologyPhilip Hamann and Neil McHugh
- Chapter 64 ComplementMatthew C. Pickering and Jyoti Bakshi
- Chapter 65 Limb anatomy and medical imagingMike Benjamin, Dennis McGonagle, Maribel I. Miguel, David A. Bong, and Ingrid Möller
- Chapter 66 Radiographic imagingEmma L. Rowbotham and Andrew J. Grainger
- Chapter 67 UltrasoundDavid Kane and Philip Platt
- Chapter 68 Magnetic resonance imagingS. Balamoody, Helena Marzo-Ortega, and Philip J. O’Connor
- Chapter 69 Computed tomographyGeoff Hide and Jennifer Humphries
- Chapter 70 Nuclear Medicine Imaging and Therapy in RheumatologyAdil Al-Nahhas and Imene Zerizer
- Chapter 71 Imaging in childrenEmma Gerety, Karl Johnson
- Chapter 72 Assessment of synovial joint fluidEngy Abdelattif, Anthony J. Freemont and Professor DC Mangham
- Chapter 73 Cardiopulmonary investigationsBenjamin E. Schreiber, Gregory J. Keir, and J. Gerry Coghlan
- Chapter 74 ElectrophysiologyJulian Blake
- Section 8 Management of rheumatic disease
- Chapter 75 Patient educationDavid Walker and Ben Thompson
- Chapter 76 Multidisciplinary treatmentSarah Ryan, Jo Adams, Anne O’Brien, and Anita Williams
- Chapter 77 Cyclooxygenase inhibitorsBurkhard Hinz and Kay Brune
- Chapter 78 AnalgesicsJoanne Foo, Benazir Saleem, and Philip G. Conaghan
- Chapter 79 GlucocorticoidsJohannes W. G. Jacobs, Cornelia M. Spies, Johannes W. J. Bijlsma, and Frank Buttgereit
- Chapter 80 ImmunosuppressantsJoanna Ledingham and Sarah Westlake
- Chapter 81 Signalling pathway inhibitorsRoy Fleischmann
- Chapter 82 Anti-cytokine biologicsAndrew J. K. Östör
- Chapter 83 Rituximab and abataceptJohn D. Isaacs and Philip M. Brown
- Chapter 84 Biologics in paediatric rheumatic diseasesDaniel J. Lovell, Nicolino Ruperto, Hermine I. Brunner, and Alberto Martini
- Chapter 85 Stem cell therapiesAlan Tyndall and Jacob M. van Laar
- Chapter 86 Tissue engineeringAndrew McCaskie, Paul Genever, and Cosimo D. Bari
- Chapter 87 Injection therapyPhilip Platt and Ismael Atchia
- Chapter 88 Diet and obesityDorothy Pattison
- Chapter 89 Alternative therapiesEdzard Ernst
- Chapter 90 Principles of upper limb surgeryIan McNab and Chris Little
- Chapter 91 Principles of lower limb surgeryPeter Wall, Matthew Wyse, and Damian Griffin
- Chapter 92 Principles of spine surgeryJeremy Fairbank and Nuno Batista
- Chapter 93 Perioperative management of immunosuppressionLoreto Carmona, Maria Galindo and Maria Martin
- Chapter 94 Vaccination in immunocompromised adultsSander van Assen and Marc Bijl
- Chapter 95 Vaccination in immunocompromised childrenMarloes Heijstek, Mario Abinun, and Nico Wulffraat
- Chapter 96 Principles of management of juvenile idiopathic arthritisNicolino Ruperto and Angelo Ravelli
- Chapter 97 Antirheumatic drugs in pregnancy and lactationTarnya Marshall, Rita Abdulkader, Poonam Sharma and Alice Malpas
- Section 9 Infection in rheumatic disease
- Chapter 98 Septic arthritis in adultsLaura McGregor, Monica N. Gupta, and Max Field
- Chapter 99 Bone and joint infections in childrenAlasdair Munro, Julia Clark, and Saul N. Faust
- Chapter 100 OsteomyelitisJeremy Field and Neil Upadhyay
- Chapter 101 Lyme borreliosisAndreas Krause and Volker Fingerle
- Chapter 102 Viral arthritisStanley J. Naides
- Chapter 103 Mycobacterial diseasesRita Abdulkader and Richard A. Watts
- Chapter 104 Brucellar arthritisEsperanza Merino and Eliseo Pascual
- Chapter 105 Parasitic infectionOlabambo Ogunbambi and Yusuf I. Patel
- Chapter 106 Fungal arthritis
- Chapter 107 Opportunistic infectionSaraswathi Murthy and Susan Hopkins
- Chapter 108 Rheumatic feverAndrew Steer
- Section 10 Rheumatoid arthritis
- Chapter 109 Pathogenesis of rheumatoid arthritisRanjeny Thomas and Andrew P. Cope
- Chapter 110 Rheumatoid arthritis—diagnosisDaniel Aletaha and Helga Radner
- Chapter 111 Rheumatoid arthritis—clinical featuresEugen Feist and Gerd-R. Burmester
- Chapter 112 Rheumatoid arthritis—managementChris Deighton
- Section 11 Spondyloarthropathies
- Chapter 113 Axial spondyloarthritisDenis Poddubnyy and Joachim Sieper
- Chapter 114 Psoriatic arthritisLaura C. Coates and Philip S. Helliwell
- Chapter 115 Reactive arthritis and enteropathic arthropathyJ. S. Hill Gaston
- Section 12 Arthropathies primarily occurring in childhood
- Chapter 116 Juvenile idiopathic arthritisEileen Baildam
- Section 13 Systemic lupus erythematosus
- Chapter 117 Systemic lupus erythematosus—clinical features and aetiopathogenesisCaroline Gordon
- Chapter 118 Systemic lupus erythematosus—managementIda Dzifa Dey and David Isenberg
- Chapter 119 Juvenile-onset systemic lupus erythematosusLouise Oni and Michael W. Beresford
- Chapter 120 Anti-phospholipid antibody syndromeMunther A. Khamashta, Graham R. V. Hughes, and Guillermo Ruiz-Irastorza
- Section 14 Scleroderma
- Chapter 121 Systemic sclerosisChristopher P. Denton and Pia Moinzadeh
- Chapter 122 Paediatric scleroderma and related disordersFrancesco Zulian
- Chapter 123 Nephrogenic systemic fibrosisCate H. Orteu
- Section 15 Myositis
- Chapter 124 Polymyositis and dermatomyositisHector Chinoy and James B. Lilleker
- Chapter 125 Paediatric polymyositis and dermatomyositisClarissa Pilkington and Liza McCann
- Chapter 126 Non-inflammatory myopathiesMark Roberts
- Section 16 Sjögren’s syndrome
- Chapter 127 Sjögren’s syndrome—clinical featuresSimon Bowman, John Hamburger, Elizabeth Price, and Saaeha Rauz
- Chapter 128 Sjögren’s syndrome—managementWan-Fai Ng, Arjan Vissink, Elke Theander, and Francisco Figueiredo
- Section 17 Overlap/undifferentiated syndromes
- Chapter 129 Overlap/undifferentiated syndromesAriane Herrick and Michael Hughes
- Section 18 Vasculitis
- Chapter 130 Vasculitis—classification and diagnosisRichard A. Watts and David G. I. Scott
- Chapter 131 Clinical features of ANCA-associated vasculitisWolfgang L. Gross and Julia U. Holle
- Chapter 132 Treatment of ANCA-associated vasculitisDavid Jayne
- Chapter 133 Large-vessel vasculitisNicolò Pipitone, Annibale Versari, and Carlo Salvarani
- Chapter 134 Polymyalgia rheumaticaBhaskar Dasgupta
- Chapter 135 Behçet’s syndromeSebahattin Yurdakul, Emire Seyahi, and Hasan Yazici
- Chapter 136 Paediatric vasculitisDespina Eleftheriou and Paul A. Brogan
- Chapter 137 Miscellaneous vasculitidesRichard A. Watts and Eleana Ntatsaki
- Section 19 Osteoarthritis
- Chapter 138 Pathogenesis of osteoarthritisTonia L. Vincent and Linda Troeberg
- Chapter 139 Clinical features of osteoarthritisAbhishek Abhishek and Michael Doherty
- Chapter 140 Osteoarthritis—managementClaire Y. J. Wenham and Philip G. Conaghan
- Section 20 Crystal arthropathies
- Chapter 141 GoutNicola Dalbeth
- Chapter 142 Calcium pyrophosphate crystal deposition (CPPD)Edward Roddy and Michael Doherty
- Section 21 Diseases of bone and cartilage
- Chapter 143 OsteoporosisKanako Yoshida, Rosemary J. Hollick, and David M. Reid
- Chapter 144 Paget’s disease of boneStuart H. Ralston
- Chapter 145 Paediatric metabolic bone diseaseNick Bishop
- Chapter 146 Disorders of bone mineralization—osteomalaciaDeepak R. Jadon, Tehseen Ahmed, and Ashok K. Bhalla
- Chapter 147 Bone tumoursThomas Beckingsale and Craig Gerrand
- Chapter 148 Avascular necrosisStefan Rehart and Martina Henniger
- Chapter 149 Renal osteodystrophyTilman Drüeke and Thomas Bardin
- Chapter 150 Skeletal dysplasiasB. P. Wordsworth
- Section 22 Regional rheumatic disease
- Chapter 151 ShoulderAndrew J. K. Östör
- Chapter 152 ElbowKaren Walker-Bone
- Chapter 153 Forearm, hand, and wristKaren Walker-Bone and Benjamin Ellis
- Chapter 154 Pelvis, groin, and thighCathy Speed
- Chapter 155 KneeRoger Wolman
- Chapter 156 Foot and ankleAnthony C. Redmond and Philip S. Helliwell
- Chapter 157 Cervical and lumbar spineDavid A. Walsh
- Chapter 158 Childhood regional conditionsKristin Houghton
- Chapter 159 Hypermobility syndromesAlan J. Hakim and Rodney Grahame
- Chapter 160 Fibromyalgia and chronic widespread pain syndromes—adult onsetAnoop Kuttikat, Nicholas Shenker and Dr Maliha Shaikh
- Chapter 161 Chronic musculoskeletal pain in children and adolescentsJacqui Clinch
- Chapter 162 Sports and exercise injuriesNicola Maffulli and Angelo Del Buono
- Section 23 Miscellaneous conditions
- Chapter 163 AmyloidosisPhilip N. Hawkins
- Chapter 164 Autoinflammatory diseasesHelen J. Lachmann and Philip N. Hawkins
- Chapter 165 PanniculitidesCord Sunderkötter and Luis Requena
- Chapter 166 Neutrophilic dermatosesPia Moinzadeh and Thomas Krieg
- Chapter 167 SarcoidosisJoachim Müller-Quernheim, Gernot Zissel, and Antje Prasse
- Chapter 168 Macrophage activation syndromeAlexei A. Grom and Athimalaipet V. Ramanan
- Chapter 169 Multicentric reticulohistiocytosisHermann Einsele and Peter J. Maddison
- Chapter 170 Inherited metabolic diseasesBernhard Manger
- Chapter 171 Rheumatological manifestations of endocrine disordersSanjeev Sharma and Gerry Rayman
- Chapter 172 HaemoglobinopathiesDavid Rees
- Chapter 173 HaemochromatosisGraeme J. Carroll, William H. Breidahl, and John K. Olynyk
- End Matter
