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Contents
- Front Matter
- Section 1 Historical
- Chapter 1 Local anaesthetic substitutes for cocaineJ. A. W. (Tony) Wildsmith
- Chapter 2 Innovative concepts in pain managementBen M. Thomas
- Chapter 3 Explaining reflex sympathetic dystrophyBrigitta Brandner
- Chapter 4 The rediscovery of paracetamolChristophe Mallet and Alain Eschalier
- Chapter 5 The pharmacology of placebosFabrizio Benedetti
- Chapter 6 Understanding the responsiveness of C-fibresJean-Sébastien Walczak
- Chapter 7 A new theory of painTony Dickenson
- Chapter 8 Three determinants of painManon Choinière and M. Gabriella Pagé
- Chapter 9 Purinergic nerves: A new type of nerveGuy Rousseau
- Chapter 10 Genetic differences in opiate receptorsJeffrey S. Mogil
- Chapter 11 Endogenous opioids in placebo-induced analgesiaVéronique A. Taylor and Pierre Rainville
- Chapter 12 Ethical pain experimentation in conscious animalsÉric Troncy and Simon Authier
- Chapter 13 Local anaesthetic creamsArgyro Fassoulaki
- Chapter 14 The back pain revolutionCathy Price
- Chapter 15 The mechanism of aspirinPierre Sirois and Pedro D’Orléans-Juste
- Chapter 16 Mechanisms of visceral pain in irritable bowel syndromeYasser Al Omran and Qasim Aziz
- Chapter 17 The effects of morphine on the CNSPhilippe Richebé and Cyril Rivat
- Chapter 18 Opioids in palliative careJoan Hester
- Chapter 19 Endogenous opioids in the CNSTony Dickenson
- Chapter 20 Spinal opioid analgesia in the ratCraig W. Stevens
- Section 2 Firsts
- Chapter 21 The key role of nerve growth factor in inflammatory pain processingPaul Farquhar-Smith
- Chapter 22 Mapping of neurotrophin receptors on adult sensory neuronsElizabeth J. Bradbury and Nicholas D. James
- Chapter 23 Plasticity in somatic receptive fields after nerve injuryStephen R. Humble
- Chapter 24 Peripheral neural mechanisms of cutaneous heat hyperalgesia and heat painAmanda H. Klein and Matthias Ringkamp
- Chapter 25 The cloning and characterization of the cannabinoid type 1 receptorMary E. Abood and Thomas Gamage
- Chapter 26 Deorphanization of ORL-1/LC132 by reverse pharmacology in two landmark studiesMark F. Bird and David G. Lambert
- Chapter 27 The capsaicin receptorIstvan Nagy
- Chapter 28 VR1 in inflammatory thermal hyperalgesiaIstvan Nagy
- Chapter 29 A signature of pain in the brainPierre Rainville
- Chapter 30 Cytokines as central to peripheral sensitization and hyperalgesiaJohn Schutzer-Weissmann
- Chapter 31 Endogenous opioids mediate stress-induced analgesiaClaudia Sommer
- Chapter 32 The first crystal structure of an ionotropic glutamate receptor ligand-binding coreKe Ren and Ronald Dubner
- Chapter 33 Control of pain initiation by endogenous cannabinoidsAndrea G. Hohmann
- Chapter 34 Peripheral analgesia involves cannabinoid receptorsJulie Desroches
- Chapter 35 Glia: A new pain targetMarzia Malcangio
- Chapter 36 The challenges of animal models of painMuhammad Saad Yousuf and Bradley J. Kerr
- Chapter 37 Mechanisms of bone cancer painLouis Doré-Savard, Nicolas Beaudet, and Philippe Sarret
- Chapter 38 The molecular structure of the μ-opioid receptorRoger D. Knaggs
- Chapter 39 The milestone effect of DNIC in our understanding of painSerge Marchand
- Chapter 40 The original description of central sensitizationSheila Black
- Chapter 41 The molecular basis for the placebo effectLesley Bromley
- Section 3 Science
- Chapter 42 Early discussions on a mechanistic approach to painRobert D. Searle
- Chapter 43 Plasticity: A key concept in painClaire Magnussen and Alfredo Ribeiro-da-Silva
- Chapter 44 The importance of descending modulatory pain systemsEnrique Collantes Celador
- Chapter 45 Nocebo and its importance in clinical practiceHelen Laycock
- Chapter 46 Mechanisms of action of acetaminophen for pain treatmentPierre Beaulieu
- Chapter 47 Making the link from “central sensitization” to clinical painJürgen Sandkühler
- Section 4 Clinical
- Chapter 48 Proof of concept: Epidural morphineVictoria Tidman
- Chapter 49 The definition of fibromyalgiaMike Shipley
- Chapter 50 The advent of patient-controlled analgesia for post-operative analgesiaSuzanne Chapman
- Chapter 51 Undertreatment of pain with metastatic cancerMatthew J. Allsop and Michael Bennett
- Chapter 52 Faces scales in paediatric pain assessmentAlison Bliss
- Chapter 53 Epidural block and phantom limb painStephan Schug
- Chapter 54 Clarifying the concept of breakthrough painGiovambattista Zeppetella
- Section 5 Mechanisms
- Chapter 55 Paediatric pain epidemiologyAlison Bliss
- Chapter 56 Recognizing the importance of HIV disease and painPeter Kamerman
- Chapter 57 Fast-acting fentanyl for breakthrough painAndrew N. Davies
- Chapter 58 The additive analgesia of adrenaline in epidural blockadePaul Farquhar-Smith
- Chapter 59 What is the clinical relevance of the Numerical rating scale for pain?Felicia Cox
- Chapter 60 Post-operative pain: Assessing the standardsJane Quinlan
- Chapter 61 Opioid-induced hyperalgesiaKirsty Bannister
- Chapter 62 The epidemiology of complex regional pain syndromeNaomi Scott
- Chapter 63 A seminal paper on the epidemiology of cancer painPaul Farquhar-Smith
- Chapter 64 Endoscopic ultrasound-guided coeliac plexus blockArun Bhaskar
- Section 6 Neuropathic
- Chapter 65 Autotomy: An early neuropathic pain modelNicholas D. James and Elizabeth J. Bradbury
- Chapter 66 Risk factors for post-amputation painTudor Phillips
- Chapter 67 The chronic constriction injury model of neuropathic painMatthew Brown
- Chapter 68 Antineuropathic medication combination therapyMick G. Serpell
- Chapter 69 Randomized controlled trial evidence for gabapentin in post-herpetic neuralgiaRajesh Gupta
- Chapter 70 Identification of the target of gabapentinoid action in neuropathic painTuro J. Nurmikko
- Chapter 71 Recognition of the importance of neuropathic pain epidemiologyMatthew Brown
- Chapter 72 Botox analgesia for neuropathic painAbdelghani Mowafak
- Chapter 73 DNIC and prediction of chronic post-surgical painSibtain Anwar
- Chapter 74 Pregabalin in the reduction of chronic pain post knee surgeryRichard M. Langford
- Chapter 75 Multidisciplinary cognitive behavioural treatment for chronic painToby Newton-John
- Chapter 76 Disability in chronic low back painRakesh Jain and Shailesh Jain
- Section 7 Psychosocial
- Chapter 77 The understanding of social effects in painAmanda Williams
- Section 8 Genetics
- Chapter 78 Congenital insensitivity to painBhagat Singh, Alban Latremoliere, and Michael Costigan
- Chapter 79 Polymorphic cytochrome P450 2D6 as the responsible enzyme of activationIngolf Cascorbi
- Chapter 80 COMT genotypes in pain responsesMatthew Lloyd Hamilton
- Chapter 81 The link between an Nav1.7 mutation and erythromelalgiaBradley J. Kerr
- Chapter 82 COMT and morphine use in cancer painFausto Morell-Ducos
- Chapter 83 Pioneering use of gene therapy for painVadym Biloshytsky and Roman Cregg
- End Matter